• We have developed a protocol for the efficient differentiati

  2018-11-08

  

  We have developed a protocol for the efficient differentiation of functional HLCs from hPSCs that does not require the addition of recombinant growth factors and is applicable to both hESCs and hiPSCs. During the development of the protocol, it came as a surprise to discover that pluripotent cox pat

• br Methods br Author contribution statement br Competing fin

  2018-11-08

  

  Methods Author contribution statement Competing financial interest Introduction Retinitis pigmentosa (RP) is just one of a group of heterogeneous inherited retinopathies and monogenic disorders that affect thousands of Americans and millions more worldwide (Daiger et al., 2013; Hamel, 20

• Partial cleavage of CXCL at the N

  2018-11-08

  

  Partial cleavage of CXCL12 at the N-terminus by distinct peptidases results in loss of chemotactic activity and impairment in CXCR4 receptor affinity (Cho et al., 2010; Delgado et al., 2001; Levesque et al., 2003). The proteolytic cleavage of CXCL12 by matrix metalloproteinase 2 and 9 (MMP-2 and 9)

• Afterward Fluc hNIS mMABs were bilaterally injected

  2018-11-08

  

  Afterward, Fluc-hNIS+ mMABs were bilaterally injected into the femoral monocarboxylate transporters and successfully monitored via both BLI and small-animal PET. After systemic administration, we were clearly able to monitor mMABs for several days via small-animal PET. Long-term cell monitoring was

• Our data have additional implications of applied

  2018-11-08

  

  Our data have additional implications of applied nature. Prospective isolation of putative “MSCs” from different tissues, based on the use of the minimal effective surface phenotype CD34−/CD45−/CD146+ (Sacchetti et al., 2007), leads to isolation of committed tissue-specific progenitors, not of broad

• Using both standard RNA seq and

  2018-11-08

  

  Using both standard RNA-seq and RNA-seq erk pathway analysis, we identified UPF1-regulated transcripts that are good candidates to be direct NMD targets in hESCs. There was considerable overlap between these candidate NMD target transcripts expressed in hESCs with previously identified high-confide

• Existing social theories explore the potential impacts of so

  2018-11-07

  

  Existing social theories explore the potential impacts of social capital on the health of older adults. Common models include social disorganisation SCR 7 (Browning, 2002) and collective efficacy models (Sampson, Raudenbush, & Earls, 1997). Although well developed and explored, these two models som

• br Discussion Persons with SCI were more likely

  2018-11-07

  

  Discussion Persons with SCI were more likely hospitalized outside of their residential canton for secondary health conditions and were also traveling longer to the out-of-canton place of hospitalization compared to the general population and persons with morbid obesity, rheumatic conditions, and

• A potential problem with the data used can

  2018-11-07

  

  A potential problem with the data used can make the results obtained by OLS invalid: the possible endogeneity of budgetary institutions since these institutions can be changed due to unsatisfactory fiscal results. The analysis presented in Giuberti (2012) indicates that both the reforms undertaken b

• This paper investigates the evolution

  2018-11-07

  

  This paper investigates the evolution of the Brazil-EU bilateral trade in the period 2002–2012 and identifies trading opportunities resulting from a trade agreement of Brazil with the EU. The paper employs a computable general equilibrium model, using the 8th version of the standard Global Trade Ana

• br Alterations in sleep architecture in patients with MD A

  2018-11-07

  

  Alterations in sleep architecture in patients with MD A significant proportion of patients with MD exhibit alterations in sleep architecture, in comparison with good sleepers. These alterations include a decrease of the slow wave sleep, reduction of latency after the first episode of REM sleep, a

• br El modelo de b squeda de

  2018-11-07

  

  El modelo de búsqueda de George Stigler La teoría de la economía de la información se enfoca en dar explicación de cómo los precios se determinan met inhibitor través de los costos de transacción en aquellos escenarios donde las empresas e individuos buscan información para tomar su decisión de v

• As for the state of Pernambuco

  2018-11-07

  

  As for the state of Pernambuco, since the year 2000, municipalities that have implemented treatment systems for municipal waste and maintained environmental conservation units tend to increase their share in tax revenue. The state\'s law aims to encourage mayors to adopt actions which lead to the ma

• In addition to promoting KC

  2018-11-07

  

  In addition to promoting KC and FB proliferation and inflammation, PK2 induced HaCat keratinocyte differentiation. The use of normal human keratinocytes (NHKs) is a primary choice to study molecular mechanisms on the regulation of epidermal differentiation markers, as an easy to handle substitutes f

• dcb Inulin Advax poly fructo furanosyl glucose is a

  2018-11-07

  

  Inulin (Advax™, β--[2→1] poly(fructo-furanosyl) α--glucose) is a plant-derived carbohydrate. It has no immunological activity in soluble form; however, once it is formulated into delta inulin microparticles, its adjuvanting activity is widely acknowledged (). Inulin was applied to enhance vaccine ef

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