• br Results br Discussion The homing engraftment of MSCs is

  2018-11-02

  

  Results Discussion The homing/engraftment of MSCs is the process by which cells migrate, engraft, and exert local functional effects. Homing involves a cascade of events initiated by shear-resistant adhesive interactions between flowing cells and the target endothelium or extracellular matrix.

• P and p are cyclin

  2018-11-02

  

  P21 and p16 are cyclin-dependent kinase inhibitors that play important roles in cell-cycle regulation and tumor suppression (Poole et al., 2004; Shapiro et al., 1998), and both are highly expressed upon senescence in MSCs. Knockdown of p21 in late-passage MSCs increases stem cell properties, includi

• br Results br Discussion hESCs

  2018-11-02

  

  Results Discussion hESCs demonstrate the potential to serve as a starting cell population for bone regeneration, and previous studies report effective differentiation of hESCs to osteogenic lineage (Arpornmaeklong et al., 2010; Kärner et al., 2009). However, it remains important to better defi

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-02

  

  Experimental Procedures Acknowledgments Introduction Spermatogonial stem Acknowledgments (SSCs) give rise to the spermatogenesis that endures throughout the life of male animals (de Rooij and Russell, 2000; Meistrich and van Beek, 1993). SSCs reside in a special microenvironment termed a n

• Our observation that EGF signaling is

  2018-11-02

  

  Our observation that EGF signaling is required for the generation of the equivalent of second-transition progenitors in hPSC differentiation cultures is in line with findings from targeting studies in the mouse that showed that EgfR/ErbB1−/− and ErbB3−/− deficient animals display impaired branching

• SOX is an essential factor in the maintenance of

  2018-11-02

  

  SOX2 is an essential factor in the maintenance of both human and murine pluripotency; however, it is upregulated, along with other pluripotency factors, in murine PGCs but not hPGCs. In this study we have clarified the mechanism of its repression in the hPGC-derived TCam-2 SEM useful handbook and s

• There are a number of potential

  2018-11-02

  

  There are a number of potential challenges to using iPSC and iPSC-derived mps1 to model human phenotype and disease. Somatic heterogeneity in iPSC lines that can occur during isolation and culture may interfere with examining genetic variants with subtle effects (Fusaki et al., 2009; International S

• br Results br Discussion With the advent

  2018-11-02

  

  Results Discussion With the advent of hESCs (Thomson et al., 1998) and hiPSCs (Takahashi et al., 2007; Yu et al., 2007), our understanding of mechanisms underlying phenomena such as cellular dysfunction in neurological diseases has advanced greatly because these hPSCs are, at least in part, ca

• T is a transposition operator of

  2018-11-02

  

  (T is a transposition operator) of dimension k be estimated for the sample , i = 1, 2,…, n . Unbiased estimates of an expected value θ and a mutual covariance matrix of the elements of this estimate for θ are known to be respectively equal to where When testing the simple pak 4 , the confiden

• br As this takes place

  2018-11-02

  

  As this takes place, we have an easily testable relation meaning that it does not particularly matter in which order the independent regressors and the independent response components are lined when takes the diagonal form. With the OLS estimate and the mutual covariance matrix of the vector c

• The modal approach assumes that different

  2018-11-02

  

  The modal approach assumes that different vibrational modes of the distributed object are controlled independently. Ref. [2] first proposed to apply this approach to controlling vibrations in elastic systems, and this concept was further developed in Ref. [3]. The problem of arranging the sensors an

• The systematic devaluation of women is further

  2018-11-02

  

  The systematic devaluation of women is further perpetuated through hegemonic power relations on the maternity ward, leading to the normalization and acceptance of healthcare providers using abusive tactics to gain control and punish disobedience (Jewkes & Penn-Kekana, 2015). Although midwives are th

• histamine-1 receptor antagonist br Conclusion Despite its li

  2018-11-02

  

  Conclusion Despite its limitations, this research addressed several aspects of fall prevention and rehabilitation. First, it histamine-1 receptor antagonist showed that frailty and falls were closely interrelated; falls may be a reliable indicator of frailty and may be systematically researched b

• In regards to the managerial

  2018-11-02

  

  In regards to the managerial implications of this buy Deferoxamine mesylate research, we understand that providers of content and services, operators and technology companies must work on triggering companies desire to access the benefits of developing a m-CRM strategy, which would help in the adva

• bcr-abl tyrosine kinase inhibitors UARS diagnosis is suspect

  2018-11-01

  

  UARS diagnosis is suspected in individuals with complaints of excessive daytime sleepiness or daytime tiredness, no OSAS and a polysomnographic study with respiratory parameters indicative of increased upper airway resistance, such as, flow limitation during sleep. They present arousals associated w

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