• br Materials and methods br Results br Discussion Heat shock

  2018-10-22

  

  Materials and methods Results Discussion Heat shock, one of environmental factors, induces HSFs, leading to induction of HSPs involved in stress responses. In human and mouse ESCs, HSPs have been reported to be associated with self-renewal of ESCs by mediating folding and nuclear delivery o

• Currently G CSF is the standard of care for

  2018-10-22

  

  Currently, G-CSF is the standard of care for the treatment of bone marrow failure from unanticipated radiation exposure or following chemotherapy. The main therapeutic benefit of G-CSF is to enhance neutrophil recovery (Dainiak, 2010). It is less clear whether G-CSF is a direct mitigator of HSPC rad

• A subset of human BMSCs appears to

  2018-10-20

  

  A subset of human BMSCs appears to coincide with a perisinusoidal population of clonogenic stromal Linsitinib noted for the expression of CD146, CD105, and ALP (Sacchetti et al., 2007). When cultured as non-differentiated cells, loaded onto an osteoconductive scaffold, and then transplanted in vivo,

• The ubiquitin proteasome degradation mechanism is associated

  2018-10-20

  

  The ubiquitin–proteasome degradation mechanism is associated with most intracellular proteins, including membrane-surface receptors (Gesbert et al., 2005; Martinez-Moczygemba et al., 2007; Rocca et al., 2001; Wauman et al., 2011). Over 60 Fbox proteins have been identified, but only a few, such as β

• The following is the supplementary data related

  2018-10-20

  

  The following is the supplementary data related to this article. Author contribution Acknowledgments Introduction Endothelial progenitor Sulindac sulfide (EPCs) circulate in peripheral blood and migrate to a site for vascular formation and repair (Asahara et al., 1997). The pro-angiogenic

• br Conclusion Human BMSCs are a promising

  2018-10-20

  

  Conclusion Human BMSCs are a promising cell type for regenerative medicine and tissue-engineering applications. They have the capacity for self-renewal and exhibit multipotent differentiation potential through which they can produce lineages such as osteoblasts, chondrocytes, and adipocytes (Char

• Keeping SCs out of the active cell cycle

  2018-10-20

  

  Keeping SCs out of the active Digoxigenin-11-dUTP Supplier phase and minimizing the risk of DNA damage may be especially important in aging and has led to a SC hypothesis of aging (Sharpless and DePinho, 2007; Beausejour and Campisi, 2006). We succeeded in transiently inhibiting DREAM expression 24h

• br Material and methods br Acknowledgement We thank Jane

  2018-10-20

  

  Material and methods Acknowledgement We thank Jane Hagelskjær Knudsen, Christian Knudsen, and Bettina Hansen for excellent technical assistance. This project was supported by Aarhus University and partially by the Lundbeck Foundation (R151-2013-14439) and Danish Council for Independent Researc

• The Sonic Hedgehog SHH pathway is active in the

  2018-10-20

  

  The Sonic Hedgehog (SHH) pathway is active in the adult SEZ, where it has been proposed to regulate cell proliferation (Ruat et al., 2012; Ahn and Joyner, 2005; Machold et al., 2003) and to modulate the migration of neuroblasts exiting the niche (Angot et al., 2008). The mosaic inactivation of the S

• br Results br Discussion Our first goal

  2018-10-20

  

  Results Discussion Our first goal in these studies was to establish an immunodeficient mouse model of hyperglycemia associated with insulin resistance and obesity that would resemble a type 2 diabetes phenotype. It was not feasible to transplant human progenitor cells into traditional models o

• CF patients either compound heterozygous I F

  2018-10-20

  

  CF patients, either compound heterozygous ΔI507/ΔF508 or homozygous ΔF508/ΔF508, lacking expression of the normal CFTR protein, manifest various features of CF disease. Individuals bearing either the ΔI507 or ΔF508 CFTR mutations at only one allele (i.e., WT/ΔI507 or WT/ΔF508) are CF carriers and ex

• The trend for increased differentiation in the field is

  2018-10-20

  

  The trend for increased differentiation in the field is paralleled by a large and increasing proportion of papers in which both cell types are being used. To analyze the validity of the “gold standard” argument that is frequently used to justify the continued use of hESCs in research, we analyzed th

• conotoxin In conclusion the MC approach

  2018-10-20

  

  In conclusion, the MC approach described in this study provides a platform to generate a population of human PAX7+ myogenic progenitors from PS conotoxin that can be terminally differentiated into MHC+ myocytes in vitro that is equivalent to iPAX7 cells. However, further development of the methodolo

• The cycling and quiescence of MaSCs has

  2018-10-20

  

  The cycling and quiescence of MaSCs has been especially difficult to study (Visvader and Stingl, 2014). It has been shown that long-lived, label-retaining cells are enriched in the MaSC/basal compartment, indicating they are slowly dividing (Shackleton et al., 2006). However, it is still unclear how

• The neurogenic to gliogenic transition of NSPCs

  2018-10-20

  

  The neurogenic-to-gliogenic transition of NSPCs is probably governed by a multi-layered system. The epigenetic status of astrocyte-specific (Takizawa et al., 2001) and neurogenic genes changes during development (Hirabayashi et al., 2009; Kishi et al., 2012; Pereira et al., 2010), critically determi

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