The present study showed that transplantation of iBAs and dB

2018-10-20

The present study showed that transplantation of iBAs and dBAs markedly reduced diet-induced obesity, dyslipidemia, and insulin resistance in mice (Figures 2, 6, and 7). The dBAs controlled insulin resistance in an UCP1-dependent fashion, strongly suggesting the UCP1-mediated energy expenditure as t

br Experimental Procedures Detailed information on the exper

2018-10-20

Experimental Procedures Detailed information on the experimental procedures can be found in the Supplemental Information File. Author Contributions Introduction Although cell-fate decisions are fairly stable in vivo, somatic Phenyl sulfate can be reprogrammed back into pluripotency in vit

The exogenous addition of osteogenically derived EVs outperf

2018-10-20

The exogenous addition of osteogenically derived EVs outperformed the effect of current osteoinductive strategies in terms of the type and/or intensity of the signaling, with the early activation of the key osteogenic commitment genes SP7 (Figure 3B) and BMP2 (Figure 3C), considered necessary and su

br Results br Discussion WNT proteins in vivo

2018-10-20

Results Discussion WNT proteins in vivo are often secreted locally and presented to responsive semagacestat in a spatially controlled manner (Alexandre et al., 2014; Clevers et al., 2014; Farin et al., 2016; Goldstein et al., 2006; van den Heuvel et al., 1989). In this study, we present a cov

To determine tissue specificity in CESC

2018-10-20

To determine tissue specificity in CESC differentiation, we performed chondrogenic and osteogenic induction under normoxia and hypoxia, respectively. Our study revealed tissue specificity indicating that hypoxia promoted chondrogenesis but inhibited osteogenesis in CESCs. This tissue specificity of

One possible explanation for the differential

2018-10-20

One possible explanation for the differential behavioral improvements in the three distinct HD mouse models could be the different cell survival rate with the highest survival rate in QA-lesioned animals. NPCs transplanted into transgenic animals generally displayed lower cell survival, a phenomenon

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2018-07-29