• Studies utilising GPR mice however report

  2022-01-26

  

  Studies utilising GPR55−/− mice, however, report different effects of GPR55 on body weight and insulin sensitivity. Genetic deletion of GPR55 appears to have no effect on overall body weight 5, 6, 7. However, one of these studies found increased fat deposition and insulin resistance in GPR55−/− mice

• To apply the recently developed GPR

  2022-01-26

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the MMP-2 Inhibitor II and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this

• As mentioned earlier two different isoforms of TFE have

  2022-01-25

  

  As mentioned earlier two different isoforms of TFE3 [16] have been reported viz. the full length (TFE3L) and smaller (TFE3S) without exon 1&2. TFE3S lacks an N-terminal acidic activation domain which is present in TFE3L hence is a dominant negative form of TFE3L [51]. This dominant negative feature

• HPF receptor br Experimental procedures br Conflicts of inte

  2022-01-25

  

  Experimental procedures Conflicts of interests Introduction Here we investigate differences in growth properties and short-term morphological changes in response to ET-1 in Chinese hamster ovary (CHO) cells stably and separately expressing ETA or ETB receptors. A stably transfected CHO syst

• In addition JMJ proteins respond to biotic stress and

  2022-01-25

  

  In addition, JMJ proteins respond to biotic stress and abiotic stress in plants. Rice genes OsJMJ704 and OsJMJ705, which have demethylase activities of H3K27me2/3 and H3K4me2/3, respectively, regulate defense-related genes and affect the defense ability of rice against bacterial pathogen Xoo (Li et

• Our results further indicate that low expression of p

  2022-01-25

  

  Our results further indicate that low expression of p300/CBP in CRC is directly associated with poor clinical therapeutic outcome of 5-FU treatment, potentially providing a new set of biomarkers to predict chemo-sensitivity. Although the ability of low expression of p300/CBP to predict poor prognosi

• Betahistine N methyl pyridyl ethylamine is a well known dual

  2022-01-25

  

  Betahistine (N-methyl-2-(2-pyridyl)ethylamine) is a well-known dual H1 cdc42 pathway agonist/H3 receptor antagonist with structural resemblance to histamine. Though it has been approved long before the discovery of H3R to treat disorders of vestibular function as Menières-Disease, the evidence for t

• We found statistically significant association between p HER

  2022-01-25

  

  We found statistically significant association between p95-HER2 levels and hormone receptor status, Ki-67 GSK343 and metastatic regions (p = 0.004,  0.05) and the median OS was 27.66 months versus 24.02 months for p95-HER2 positive and p95-HER2 negative BC patients respectively (p > 0.05). Finally,

• Introduction Hedgehog HH signaling regulates development

  2022-01-25

  

  Introduction Hedgehog (HH) signaling regulates development, cell proliferation, and tissue repair [1], [2], [3]. In mammals, HH signaling is activated by 3 ligands: Sonic hedgehog (SHH), Indian hedgehog (IHH), or Desert hedgehog; SHH is the most widely expressed in adult tissues [3]. The primary re

• Urinary As species monomethylated MMAV percentage might incr

  2022-01-25

  

  Urinary As species monomethylated (MMAV) percentage might increase and As species dimethylated (DMAV) percentage might decrease with increasing As exposure dosage (Lindberg et al., 2008). The limited methylation capacity associated with increased of As exposure dosage might probably explained throug

• NPxY was recognized as the first

  2022-01-25

  

  NPxY was recognized as the first short signal sequence motif in the cytoplasmic domain of membrane receptors and proteins with critical roles in internalization and trafficking of receptor molecules [130]. Including LDL receptor, beta-1 integrin, megalin, beta-amyloid precursor protein, EGF receptor

• To apply the recently developed GPR ligands to CNS disorders

  2022-01-25

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the Cy5 amine (non-sulfonated) australia and whether activation or blockade of this receptor has any consequence on the activity of the neuronal c

• Introduction Molecular imprinting technology is a method tha

  2022-01-24

  

  Introduction Molecular imprinting technology is a method that combines the material chemistry, biochemistry, and polymer chemistry and has the ability to specifically identify target analytes on shape, size and functional groups. Molecular imprinting polymer (MIP) is developed based on molecular im

• Little is known about the endocrinological control of reprod

  2022-01-24

  

  Little is known about the endocrinological control of reproduction in polychaetes. In vertebrates, gonadal maturation is regulated by the hypothalamo-pituitary-gonadal axis. GnRH, GTHs, and steroid hormones are involved in this axis (see Okubo and Nagahama, 2008). In two polychaete species, Perinere

• br Materials and methods br Results br Discussion Importantl

  2022-01-24

  

  Materials and methods Results Discussion Importantly, we observed that treatment with DA3-CH could reduce the pathophysiological processes in the hippocampal CA1 area after SE. At present, the unimolecular dual incretin receptor agonist has been developed as a treatment for type 2 diabetes,

15877 records 482/1059 page Previous Next First page 上5页 481482483484485 下5页 Last page