• Abbas et al studied the mitigation of

  2020-10-01

  

  Abbas et al. studied the mitigation of ASR in their corresponding study by incorporating RHA [1]. These researchers used Ordinary Portland Cement (OPC), four different percentages (i.e., 10%, 20%, 30% and 40% by weight of OPC) of RHA and reactive aggregate (sand from Dolomite-limestone rock) in thei

• The importance of EBI for B

  2020-09-30

  

  The importance of EBI2 for B cell function was first suggested by the dramatic upregulation of this receptor in EBV-transformed Pentamidine and further inferred from its regulation in activated and GC B cells (Birkenbach et al., 1993, Glynne et al., 2000, Shaffer et al., 2000). An involvement of EBI

• br E intracellular localization br Regulation of E by

  2020-09-30

  

  E1 intracellular localization Regulation of E1 by other post-translational modifications Concluding remarks Acknowledgments We apologize to those whose work was not included because of space considerations or whose papers were unintentionally omitted. We thank Dr Peter Bullock (Tufts Uni

• It was thus found that E plays an important

  2020-09-30

  

  It was thus found that E1 plays an important role in G. intestinalis biology. Inhibiting E1 expression by RNA antisense in trophozoites was lethal while E1 overexpression induced a five-fold increase in cyst formation during encystation. The changes in E1 location during this process and its localiz

• Pranlukast br Sphingosine kinase One of the

  2020-09-29

  

  Sphingosine kinase One of the enzymes closely related to DGKs are the sphingosine kinases (SKs). These enzymes catalyze the conversion of sphingosine (Sph) to sphingosine-1-phosphate (S1P). SKs and DGKs are closely related lipid kinase in term of basic enzymology and the mechanism of regulation a

• Recently Schenck et al identified an active

  2020-09-29

  

  Recently, Schenck et al. [25] identified an active site asparagine 222 (N222) residue in the Glycine max TyrAp/PDH (GmPDH1) that is responsible for its prephenate substrate specificity. Mutating the single N222 into an acidic residue (i.e. aspartate, D) in the legume TyrAp/PDH shifted from prephenat

• To overcome problems with the biochemical reconstitution of

  2020-09-29

  

  To overcome problems with the biochemical reconstitution of these heterodimeric cytokines fusion strategies linking both subunits together have been proposed inspired by the “hyper-IL-6” [28]. Much like fusing a protein to a solubility enhancing protein such as MBP or SUMO, fusing two subunits of a

• Tumor associated macrophages TAMs one of the

  2020-09-29

  

  Tumor-associated macrophages (TAMs)—one of the limiting factors in anti-tumor immunity—are associated with the poor clinical outcome in most carcinomas, owing to their potential to promote angiogenesis and local invasion, increase the metastasis of tumor cells, and inhibit the anti-tumor immunity.1

• SCH-900776 br Conclusions br Acknowledgments This work was s

  2020-09-29

  

  Conclusions Acknowledgments This work was supported by a grant from NIH from the National Institutes on Arthritis and Musculoskeletal and Skin Diseases [AR056092]. Introduction Prior exposure to stressors has been consistently associated with the manifestation and/or exacerbation of psychi

• It is well known that

  2020-09-29

  

  It is well-known that corticotropin-releasing factor (CRF) exerts its biological functions through binding to type-1 (CRF1) and/or type-2 (CRF2) receptors. Several clinical evidences suggest the association of a high level of CRF and the onset of anxiety and depressive disorders.2, 3, 4, 5, 6, 7 Si

• Our results also showed that the highest

  2020-09-29

  

  Our results also showed that the highest dose of Astressin2-B increased the rewarding effects of cocaine, since non-defeated animals treated with this dose developed CPP with a sub-threshold dose. We monitored the acute effects of 30 µg/kg of Astressin2-B and found an increase of anxiety in the open

• Alternatively procedural factors may have

  2020-09-29

  

  Alternatively, procedural factors may have contributed to the conflicting results. For instance, in order to have a more circumscribed area of drug diffusion, a volume of 0.05μl was injected in experiment 1b, which is four times lower than the one used in the mentioned plus-maze investigation. Besid

• Multiple lines of evidence now

  2020-09-29

  

  Multiple lines of evidence now indicate that mitochondrial decay is a fundamental factor that leads to alterations in energy metabolism in the aged heart (Hagen et al., 2002, Judge and Leeuwenburgh, 2007, Lesnefsky et al., 2001c). Nevertheless, the exact biochemical events that cause such an alterat

• br Experimental methods br Results and discussion br

  2020-09-29

  

  Experimental methods Results and discussion Conclusions Here we describe the first reported method for high-yield DMAP of active and soluble mature CPG2 (in the absence of the leader peptide) and its individual catalytic and dimerization domains in E. coli. Such a method is of key importan

• A similar pattern was observed for both tissues of P

  2020-09-28

  

  A similar pattern was observed for both tissues of P. harpagos, evidencing the absolute predominance of acetylcholinesterase. As observed, no effects were attributed to Iso-OMPA. The hypothesis that the major cholinesterasic form is AChE was reinforced considering the higher hydrolytic activity, whi

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