• br NADH and NADPH Turnover and the Putative

  2020-08-03

  

  NADH and NADPH Turnover and the Putative Role of Alternative NAD(P)H Dehydrogenases Still very little is known about the metabolic function of external and internal alternative NADH:UQ oxidoreductases, and almost nothing is known about the mechanisms underlying their metabolic regulation, especia

• The identification of a gatekeeper mutation

  2020-08-03

  

  The identification of a gatekeeper GX-674 also suggests that alternative DDR2 inhibitors may be required to overcome acquired resistance. Additional DDR2 inhibitors that have been isolated include the recently identified alkaloid natural products discoipyrroles A-D and the chemotherapeutic Actinomy

• br DDR SIGNALING NETWORKS DDR has been implicated in

  2020-08-03

  

  DDR2 SIGNALING NETWORKS DDR2 has been implicated in a number of cancer types and has been shown to play a role in driving proliferation and SR3335 (see Borza and Pozzi and Valiathan et al. for recent excellent reviews on this topic). There is limited information available on the signaling pathway

• In the meta analysis apart from Kano s study

  2020-08-01

  

  In the meta-analysis, apart from Kano\'s study (Kano et al., 2012), we found that the significant associations of previous studies were marginal and changed along with the genetic effect models (Porcelli et al., 2015; Terock et al., 2018). Given the inconsistency in genetic effect models and the het

• br Materials and Methods br Results br Discussion Rats have

  2020-08-01

  

  Materials and Methods Results Discussion Rats have a low cholesterol ap4 rate compared to humans. Thus, the inclusion of cholic acid in a cholesterol diet has been widely used to improve cholesterol absorption and induce hypercholesterolemia in rats for studying human cholesterol metabolism

• Compound proved to be only weakly active

  2020-07-31

  

  Compound proved to be only weakly active as an antagonist of CRTh2, with binding affinity () of approximately 9.2μM (). Incorporation of various substituents at the 5-position () improved affinity by 2–3-fold. Incorporation of methyl at the 2-position () also increased binding by threefold. The eff

• lxr agonists br Materials and methods br Results br Discussi

  2020-07-31

  

  Materials and methods Results Discussion Conclusions Acknowledgments Introduction Residues and metabolites of pharmaceuticals that reach aquatic systems can exert adverse effects on non-target organisms (Kasprzyk-Hordern et al., 2008, Brausch and Rand, 2011, Verlicchi et al., 2012,

• Clotrimazole belongs to the imidazole group often

  2020-07-31

  

  Clotrimazole belongs to the imidazole group, often used for treatment of fungal infections. It decreases fungal growth by inhibiting CYP51 conversion of lanosterol to ergosterol, an essential component of fungal cell membranes (Rozman and Waterman, 1998). As CLO acts via the inhibition of the CYP51-

• How does APC C recognize its substrates

  2020-07-31

  

  How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac

• Some E s have been shown to

  2020-07-31

  

  Some E2s have been shown to bind to co-factors that can alter the activity or subcellular localization of the recruited E2 [28]. One example is the CUE1 co-factor which recruits the cytoplasmic UBC7 (UBE2G2) E2 enzyme to the endoplasmic reticulum (ER) where it participates in the degradation of misf

• DBH gene transcription is also regulated by AP

  2020-07-31

  

  DBH gene transcription is also regulated by AP1 proteins, especially c-Jun and JunD (Swanson et al., 1998). Overexpressed Egr1 has been shown to suppress the c-Jun mRNA ag1478 induced by interleukin-17 (Faour et al., 2005). Levkovitz and Baraban (Levkovitz and Baraban, 2002) showed that the zinc fin

• While desolvation appears to play a universal role in the

  2020-07-31

  

  While desolvation appears to play a universal role in the binding of the nucleotide substrate during TLS, the molecular forces regulating the polymerization step are more divergent as they depend upon the physical nature of the DNA lesion. For instance, π-stacking interactions play a large role in f

• The residue selectivity of vCPH was investigated using

  2020-07-31

  

  The residue selectivity of vCPH was investigated using peptides based on PA-Hyp-KPAPK (PA-Hyp-K-X-APK with the X position being varied); the results revealed no evidence of reaction between vCPH and other proteinogenic amino acids, indicating that vCPH is highly selective for prolyl-residues (Supple

• br Introduction Alkylating agents which interact directly wi

  2020-07-30

  

  Introduction Alkylating agents which interact directly with DNA to form covalent bonds have an important therapeutic role in anticancer treatment.1, 2, 3 Nitrogen mustards were the first effective antineoplastic drugs and are still commonly used in chemotherapy. Their mechanism of action is based

• br Results br Discussion The current study integrates result

  2020-07-30

  

  Results Discussion The current study integrates results from both a new screen in 3D culture and more conventional screens in 2D culture. Screening in 3D culture has the advantage of sensitizing KRAS mutant flt3 to Raf-MEK-ERK pathway inhibition (Figure 1D), so that the phenotypes observed ma

15877 records 792/1059 page Previous Next First page 上5页 791792793794795 下5页 Last page